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New target for Multiple Sclerosis (MS)

New target for Multiple Sclerosis (MS)

Article by Katewinslet

Multiple Sclerosis(MS) is a type of autoimmune disease. The sheaths of axons is damaged by immune cells. The mechanism of this kind of autoimmune is not clear and there is still not cure for this disease. MS severely damage the function of neuron cells in brain and spinal cord. Finally, it will progressively affect cognitive ability.Although not very clear, the hypothesis of the mechanisms of MS include genetics, environmental factors, infections. Based on these hypothesis, people try to find disease targets for the treatment. Liu et al., recently publish a paper in Nature Medicine about a new target for Multiple Sclerosis and hereby the related treatment. The authors search the genetic profile of MS and found IL-7 and IL-7R is closely linked to the MS disease. Further more they tried to confirm the hypothesis and understand the mechanism underlying it. Always, the T helper cells are responsible for the self immune mechanism of MS. The authors found IL-7, mediated by IL-7R, activates T helper cells by directly expand the quantity of T helper cells and help the survival of T helper cells. IL-7-IL-7R together activates Janus kinase-signal transducer and activator of transcription-5 (JAK-STAT5) pathway and the proapoptotic factor Bcl-2 and Bax. Based on these findings, they used IL-7 inhibitor to successfully reverse the apoptotic activity of MS and prohibited the process of MS in animal model.

Thus, a new target of MS is born to hopefully reverse the disease progress of MS. Not only for MS, the IL-7-IL-7R-T helper cells mechanism provides a novel way to treat other autoimmune disease.Related to New target for Multiple Sclerosis (MS)

While we have seen the interesting finding that caspases mediate chronic neuronal degeneration or even normal neuron function like Long Term Depression (LTD). It is no doubt the major role of caspases in neuron is still mediating apoptosis.

In a recent paper in JBC (1), the author conclude part reason of Alzheimer’s Disease in Down Sydrome, if not all, is becuase of the activation of caspase-3 and caspase-9. People with Down Sydrome will inevitably develop Alzheimer’s Disease if he can survive to middle age. A protein called RCAN1 contribute to it. The elevated level of RCAN1 in the brain of AD patient will activated caspase-3 and caspase-9, thus induce the apoptosis of neuron. The inhibition of caspase-3 could prevent the toxicity of RCAN1 and block A? induced neuronal death.

Another evidence that caspase-3 could be the target of Alzheimer’s Disease.

As we all think caspase-3 is necessary for apoptosis, we need to think again. Neuron cells exhibit nonclassical apoptosis-like pathway without activating caspase-3. Zillkova et … Cell cycle is now linked with apoptosis by specific splicing pathway

As my last several blogs metioned, Bcl-2 family is a critical oncogene family protein. It mediates typical blood malignant type, like CLL. Moore et al …

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Natural Treatment For Multiple Sclerosis To Safely Manage Your Condition

Natural Treatment For Multiple Sclerosis To Safely Manage Your Condition

Article by Roberta Barrow

A condition affecting the brain nerves, the spinal cord as well as the further components of the body’s central nervous system is known as Multiple Sclerosis. This condition is said to be caused by the abnormal immune system functioning. Immune cells of the body unusually attack the optic nerves, the brain nerves, spinal cord and the nervous system, thereby slowing down nerve impulses. Diagnosing MS may include identifying medical records or history of the patient as well as performing neurological and physical exams.

Symptoms. A person with MS suffers from abnormal vision (blurred, double vision, inflamed optic nerves, eye pain, and involuntary movement of the eye), weak muscles (can eventually end to paralysis), paresthesia (change or loss in sensation, one of the earliest symptoms of MS), malfunction of the bowel and bladder, coordination and balance problems (poor balance, tremors, uncoordinated movement, vertigo, dizziness), cognitive malfunction (memory problem, difficulty in concentrating), change in behavior (mood swings, depression), pains (of various types like in the face, leg, back and arms), fatigue and sexual malfunction.

The exact cure for MS is yet to be discovered, but there are natural treatments that can help manage and alleviate the symptoms.

Diet. A patient diagnosed with MS need to implement an optimal diet of whole and plant-based foods, with fish as supplement. There are a lot of foods nowadays with hidden saturated fats that are not good for the health. Fruits, vegetables, legumes, nuts, grains and seeds, egg whites and seafood should be included in the MS diet. Foods to avoid include meat, processed meat, egg yolk, dairy products, commercial baked products and other fatty or oily foods. Although there are many foods prohibited to the MS patient, this change of diet should be perceived positively. It should be valued through the benefits that can be experienced by the change in habits and diet, rather than thinking of being deprived to eat. Food products and ingredients that are allowed for the MS patient to take can be turned into great-tasting meals and dishes too. There are also anti-inflammatory diets used particularly to help MS sufferers like MacDougall modified diet and Swank Diet.

Meditation. Meditating will greatly help in the healing process, especially for chronic ailments like Multiple Sclerosis. Meditating twice daily is recommended by experts. The more frequent you meditate, the more benefits you can expect to feel. When meditating, you need to concentrate all of your energies toward healing. Make sure that no energy will be wasted on being overactive for no special reason.

Exercise. Treatment plans for MS should essentially include exercises. Regular and gentle ways of exercising can assist in maintaining the patient’s muscle control and flexibility. These exercises can also help to offset weakening effects of the condition. It is, however, important not to overdo your exercises. Tai Chi, Qi Gong, Yoga, biking, swimming and even plain walking are typical exercises recommended for MS patients. Keep away from strenuous types of workout that may increase the core temperature of the body and thus worsen symptoms of Multiple Sclerosis. Discuss with your physician what exercises are best to perform.

About the Author

Discover how to successfully reverse the symptoms of Multiple Sclerosis through How To Reverse MS Now!. Find out how to naturally treat these debilitating MS symptoms using another recommended source of information, Natural Multiple Sclerosis Treatment System.

Is Cannabis Use Beneficial For Multiple Sclerosis?

Is Cannabis Use Beneficial For Multiple Sclerosis?

Article by Sutiyo Na

Some medical researchers have grouped together to look for tests that can evaluate some extracts of the cannabis such as the cannabidiol or CBD and the delta9-tetrahydrocanabinnol or the THC. According to their findings, a therapeutic advantage and benefit can be derived from the combination of the two aforementioned extracts, especially towards the relief of spasticity involved with multiple sclerosis.

What is spasticity?

Spasticity is a general term given to involuntary muscular contractions which are very common to multiple sclerosis. Many treatment modalities directed at this symptom of MS have rendered themselves somewhat ineffective and intolerable.

In this study by experts form the Global Neuroscience Initiative Foundation, namely Marie Rowland and Shaheen Lakhan, certain side effects from cannabis have the ability to limit spasticity. The intoxication from cannabis, otherwise termed as marijuana, is actually necessary for limiting spasticity. But of course, the effects vary depending on how much cannabis was taken to intoxicate. The study they conducted in Los Angeles indicates that cannabinoids have a therapeutic effect for multiple sclerosis.

The trial

People with MS who have significant leg muscle spasticity were called in from different places to take part in this experiment. There were sixteen respondents, six had primary – progressive while ten of the respondents had the secondary – progressive type. The average age was forty-six years old having MS for an average of fifteen years.

There were three groups, each of which has been allocated a certain treatment. One was set for cannabis oil, the second for tetrahydrocannabinol, which is a cannabis constituent. And lastly, the placebo capsules which only contained vegetable oil.

The multiple sclerotic people were instructed to take the drugs and reach a specific level of medication in the first five weeks of the trial, but before passing eight weeks of monitoring.

Those who took the treatment, including the physicians, have no idea which mode of treatment has been taken. Everything will only be found right after the results of the study has been determined. Physicians were tasked to assess the stiffness of the muscles and their mobility every couple of weeks. Aside from physical assessment, postal questionnaires were also utilized. All of the side effects were to be taken down.

Physicians measured the muscle tone by using a categorical scale that holds 0 as normal, 1 as mild elevation, 2 as more marked elevation, 3 as considerable increase, and 4 as rigid limb upon flexion or extension for both the arms and the legs. They had to have a score of two for inclusion.

The results

Most of what came out as results were initially anecdotal at best and somewhat difficult to interpret. But after some time of further analysis, the meaning of the results was finally determined.

The cannabinoids that were taken orally were most helpful. However, such result was not observed in all patients, only in those who smoked the cannabis. Actually, other tests in the previous years have shown their results regarding the effect of cannabinoids in controlling spasticity.

About the Author

Find more Tips on How To Treat Multiple Sclerosis, visit: www.multiplesclerosis.getmytips.com

Multiple Sclerosis – Prevention And Treatment

Multiple Sclerosis – Prevention And Treatment

Article by John Daniel Rivera

Multiple sclerosis (MS) is a disorder characterized by destruction of the myelin sheaths, the protective outer coverings of the nerves within the central nervous system (the brain, optic nerves, and spinal cord). Myelin sheaths are composed mostly of fats; they insulate the nerves and preserve the speed of electrical transmissions. In MS, patchy areas of the sheaths are destroyed (demyelinated) and replaced by scar tissue (called plaques) a process known as sclerosis at multiple sites throughout the central nervous system (hence the name of the disorder). Sclerosis impairs electrical conduction, thus reducing or eliminating transmission of nerve impulses within the affected areas. When severe the disease may destroy the inner cables of the nerves (axons), causing irreversible damage. Symptoms wax and wane unpredictably and vary widely from patient to patient. For example, sclerosis of the optic nerves may cause vision disturbances, and sclerosis of the nerves that control the muscles may lead to spasticity, weakness, muscle spasms, or paralysis. Different symptoms may occur in combination and may vary greatly over time.The initiating cause is unknown; however, current research indicates that MS is an autoimmune disorder, in which the immune system attacks some of the body’s own cells, mistaking them for foreign invaders. MS is rare in children and in people over 60; the first episode usually occurs between the ages of 20 and 50. MS occurs in two major forms. In relapsing/ remitting MS, which afflicts about 70 percent of MS patients, a series of flare-ups or attacks are separated by periods of normal or near normal health. Such remissions may be short or may last for months or years. In a few cases, remission is permanent neurological deficits. The other type of MS, chronic /progressive, gradually worsens without remission. Rarely is progression so rapid or severe that survival is limited to only months or a few years. Women are affected more often the men. Average survival after diagnosis is more than 35years, but destruction of the myelin sheaths can eventually result in a combination of nerve, muscle, and occasionally, brain damage. However, many people retain much of their function for years and are able to pursue a wide range of normal activities with the help of supportive therapy. Current treatment is aimed at reducing the frequency and severity of attacks, relieving the problems caused by neurological deficits, and providing psychological support.Continued in part 2


About the Author

This article is written by john daniel rivera who is an advocate for natural health and healing, and has been in the field of health for quite a few years. He is interested in illuminating individuals and helping others return to a better quality of health. If you would like to learn more about his approach, please feel free to visit http://www.curewithinoneminute.com

Defining and describing multiple sclerosis

Defining and describing multiple sclerosis

Article by Groshan Fabiola

Using medical terms we can say that multiple sclerosis is an autoimmune disorder that affects the central nervous system, meaning the brain and the spinal cord.

Studies done on groups of individuals with the disorder has come up with the conclusion that women are much more affected than man. Still, in both cases the disease begins between the ages of 20 to 40.

Scientists and doctor have yet to give a conclusive answer to the question: what causes multiple sclerosis? Still some breakthroughs have been made and with the help of modern medicine they have discovered that the factor that determines the onset of the disease may be the damage done to the myelin sheath, the myelin being the material that surrounds the nerve cells protecting them. Being a progressive disease, the symptoms of the patients present are only going to get worse over time. As said before, because the layer of myelin is destroyed, the body ends up damaging its own nerve cells, thus leading the nerves system to a total and fatal collapse.

Another fact that results from the destruction of myelin is inflammation. To even worsen things inflammation may to often slow or block the nervous impulses from reaching their designated target. Because of this symptoms specific to multiple sclerosis may appear. Flare ups or repeated inflammations can occur in different areas of the brain or the spinal column.

Attack intensities may vary a lot over time, the bad thing being that they vary for the worse. At the beginnings episodes may last a couple of days, but as time goes by and the disease worsens, they tend to last longer and longer sometimes reaching the order of month. The time between episodes may also tend to get smaller and smaller with the passing of time and the agravation of the disorder.

Scientist have also come up with what is believed to be a second trigger in the disease. Studies made on patients with multiple sclerosis have revealed that these people have a larger number of immune cells than normal healthy people do. Genetic defects or the actions of viruses are thought to cause symptoms to appear. The genetic factor has revealed that the most likely to develop this disorder are the Caucasians. Also geographical studies made on different populations of people around the globe have determined that an environmental factor may also be involved in triggering the disease.

About the Author

We recommend you clicking this site http://www.multiple-sclerosis-center.com for more multiple sclerosis subjects like multiple sclerosis information or multiple sclerosis treatment

Symptoms for multiple sclerosis

Symptoms for multiple sclerosis

Article by Groshan Fabiola

As in other illnesses and diseases one can tell if someone has disorders by analyzing that person to see if certain symptoms are present. Finding and identifying the symptoms can be quite tricky sometimes. First of all not all the people come down with the same symptoms and on top of that is the fact that some of the symptoms that the patient may be experiencing are possible to be mimicking the symptoms from other diseases. If a person has one or a few symptoms related to the ones for multiple sclerosis it doesn’t necessarily mean that the individual has the disorder.

Disease may have a wide variety of symptoms but in the case of multiple sclerosis you might say there are quite many.

Some of the first and most apparent symptoms may be physical problems in the eyes. A person can experience blurred vision or even, as in some cases, dioplia ( double vision). Pain can also appear when moving an eye; some more acute symptoms will even involve the loss of vision in one eye. Other disorders in the field of vision may include moving or jumping of the image that the patient is currently viewing. One or more numerous floaters may also appear in one or both eyes of the person suspected to have multiple sclerosis.

The perception through touch, of the world around him, can also change. Different sensations of itching and burning may appear on different occasion and in different places on the person’s body. The feeling of pins or needles being poked in to the skin may also be felt. Electric shocks may be felt by the patient on the neck and upper back areas. A state of general fatigue may sometimes install in the patient with numbness or tingling in the arms or legs. It is not unlikely for the patient to feel heavy or have the sensation of weakness in one arm or a leg. Loss of strength and coordination may be present at some time during the diseases development in the patient. Dizziness and vertigo are again very common symptoms. A more severe sign would be the tightness in the chest that the patient could be feeling.

The actions that the disease has on the body are actually very serious sometimes leading to limping n the legs or even, as in some severe cases, paralysis.

Involuntary reactions may appear in the patient like seizures, tremors and even spasticity.

Headaches, changes in behavior, depression and sexual difficulties might also be signs of multiple sclerosis in the patient.

About the Author

We recommend you clicking this site http://www.multiple-sclerosis-center.com for more multiple sclerosis subjects like multiple sclerosis information or multiple sclerosis information

Drug treatments for multiple sclerosis patients

Drug treatments for multiple sclerosis patients

Article by Groshan Fabiola

Studies have shown that multiple sclerosis is very hard on people affecting some 2 in every 1000 persons. Even more problematic is the fact that some 50 % of these people are left unable to walk after some 15 from the onset of the disorder. A total cure has not yet been developed but scientists and doctors are working on treatments that will at least slow down the action of the disease. The good thing is that they really are starting to understand how the disorder works and the way it affects people, plus a new kind of monitor treatment is being developed as we speak. The bases for some new treatments have this way been developed; they include the using of disease modifying drugs that will have quite a remarkable impact on the natural course of the disease, significantly slowing it down.

Still some of these drugs are yet to be approved and clinical test are still in progress to really understand if the drugs are working and what the side effects would be. Scientist and doctors from all over the world gather more and more often to discuss their new findings and believes regarding multiple sclerosis. Because of all this effort put into defeating this disease a lot of progress has been made.

It has been seen that the disorder starts manifesting itself clinically in patients after a period of about 5 years when the disease enters the secondary progressive phase. Physical symptoms are more clear now and start affecting the patient on a regular bases, each time stronger than the last. Relapsing- remitting patients have shown to have a benign course of the disease developing little or no affect from disabilities after a period of about 10 years. Trying to predict the appearance and actions of the disabilities in the cases of multiple sclerosis patients has proven to be a major challenge for doctors. The fact is that this disorder is very variable and has a sudden way of acting.

Tests and researches done by scientist have shown that there actually are some factors that make prognosis in multiple sclerosis quite unfavorable. Male sex has been proven to be one of the grater factors to affect prognosis; also the age at witch the disease begins its onset. Some motor and cerebral signs that are present on the onset might be also be affecting the prognosis. A very confusing fact for the doctors is the rate at witch the patient has its attacks ( short intervals pose a great problem), and also the high relapse rate in the early years of the disease. Incomplete recovery after relapses can also cause a great problem if the doctors are to correctly anticipate the path of the disease.

About the Author

We recommend you clicking this site http://www.multiple-sclerosis-center.com for more multiple sclerosis subjects like multiple sclerosis treatment or symptoms of multiple sclerosis

You have Been Diagnosed with Multiple Sclerosis: What Now ?

You have Been Diagnosed with Multiple Sclerosis: What Now ?

Article by Rob Parker

Being diagnosed with multiple sclerosis is a very hard situation for anyone to be in. In the immediate aftermath, you are probably experiencing feelings of anger, frustration, and fear. These emotions are natural, and it may be some time before you feel that you have regained some equilibrium in your life. While these feelings may never go away entirely, the first thing you must realize is that MS is not a fatal disease, nor does the diagnosis mean that you will begin experiencing the symptoms right away. Many people diagnosed with MS have many years of healthy living ahead of them; some even find that they are able to outperform their friends at various activities right through their senior years. Because most MS diagnoses take place between the ages of 20 and 40, individuals who have the disease often have much longer to deal with the reality than those diagnosed with other disorders. It is important to realize that while definitely frightening, this diagnosis is not a life sentence.

You no doubt received your diagnosis via your family doctor; he or she should give you contact information on specialists in this field. You and your family should try to make an appointment right away, and discuss the various options available. There are several different treatments that can stagnate the development of multiple sclerosis symptoms and reduce the risk of new ones occurring. The sooner you begin these treatments, the better.

Your family is going to be an integral part of the new road that you are on. You should resolve not to keep your pain or your frustration to yourself, as these feelings will magnify without an outlet. A good thing to do is to find a counselor who can work with you and your whole family to facilitate discussion; this is particularly important if you are married, as the diagnosis will likely put a whole new stress factor on your relationship.

Finding information about multiple sclerosis is one of the best ways to combat the fear that the disorder can cause in many people. Again, because of the young diagnosis, many people’s decisions to have families of their own can be affected when the disease is confirmed. It is imperative for you to understand how the disease works and how this may or may not affect those around you and your ability to have children.

A multiple sclerosis diagnosis is truly a blow. There is little comfort that can be drawn outside of the strength of the individual; in the final equation, it is how you deal with your new situation that will determine your life from here on out. Remember that this diagnosis does not mean an immediate end to life as you know it. You do have a difficult reality to live with, but for many, the symptoms will not manifest until much later in life.

About the Author

For more about this article or for more Multiple Sclerosis information, visit MSProgram.ca.

Living with Multiple Sclerosis

Living with Multiple Sclerosis

Article by Rob Parker

Although it is a disease that has seen a major expansion as far as awareness over the past couple of years, most people don’t know a lot about multiple sclerosis. The impact of the disease, what causes it, the different types, its treatments, and what a person living with MS can expect are all areas shrouded in mystery.

When it comes to living with multiple sclerosis, then, the first step is to become as educated about the disease as possible. There is always a certain amount of fear after diagnosis is made, and this fear is both natural and abiding. Don’t let it keep you from doing in-depth research on the disease, as many times the facts you find may actually serve to alleviate some of the fears involved.

Different people will react to their diagnosis in different ways. There will be a certain amount of anger that arises from time to time when confronting the fact that you have the disease. It can be very hard to channel this anger, but refusing to acknowledge the feeling is not a good tool. Other people in your life – family, friends, and spouses above all – will also feel the effects of multiple sclerosis in their lives even though they will not display the symptoms. If you don’t feel like talking about it, that is understandable, but sometimes it can help if you can point the people who care about you to other sources of information that can help them understand the disease.

During the research process, you will undoubtedly come across several drugs and treatments which can help alleviate, delay, or prevent some of the symptoms of the disease. It’s really important to explore the options here with your doctor, and once you have settled on a plan to follow it every day. Many of the treatments have proven to be very effective in preventing symptoms or lessening the effects and duration once they occur.

One thing that can be very hard when living with MS is facing a future in which the specter of the disease looms large. Many people diagnosed with MS will avoid support groups and the like as they often include patients in later stages of the disease. While this type of gathering may indeed be intimidating, it can also be extremely uplifting to take note of how these people deal with their day to day realities and recoveries. Let them motivate you, and don’t be afraid to feel a connection with them.

Living with multiple sclerosis on a day to day basis will bring sundry reactions in different people. It’s always important to have a support network about which you feel confident and secure, and a plan for the future.

About the Author

Approximately 50,000 Canadians have MS and dealing with it can be hard, but contacting the Multiple Sclerosis Society of Canada is a good way to get support.

Multiple sclerosis: an unpredictable disease

Multiple sclerosis: an unpredictable disease

Article by Sharon Bell

In some people, it is a mild illness. In others, it can lead to permanent disability. This is the nature of multiple sclerosis, an unpredictable disease that affects 300,000 people in the United States alone.

Myelin is a fatlike substance that covers the nerve fiber found in the brain and spinal cord. It is an essential part of the nervous system since it enables the nerves to carry electrical impulses to and from the brain where they can be acted upon by the appropriate part of the body.

In multiple sclerosis (MS), myelin is damaged for unknown reasons. As a result, normal nerve impulse transmission is impaired and the person experiences a variety of symptoms depending on which part of the brain and spinal cord is affected.

“An electrical short circuit develops, and normal electrical impulses cannot be carried by the nerves. The type of symptoms that result depends on where in the brain and spinal cord this process takes place, but usually, multiple sites are involved. Myelin has some ability to repair itself, but with repeated attacks of inflammation, scarring (sclerosis) takes place and per?manent loss of function may result,” according to Dr. Timothy A. Pedley in “The Columbia University College of Physicians and Surgeons Complete-Home Medical Guide.”

MS is believed to be an autoimmune disorder wherein the body develops antibodies to attack myelin. Some say a virus is behind this disorder. The victims fall between the ages of 20 and 40, and are usually women. Symptoms may appear slowly or rapidly and the dis¬ease may disappear from time to time.

In the early stages, MS may be marked by blurred or double vision, difficulty walking, weakness, numbness or a tingling sensation. Later, the patient may suffer from tremors, loss of bladder or bowel control, diffi¬culty speaking, and impotence.

“It is not possible to provide a typical picture of multiple sclerosis. Some of the common symptoms, however, include loss of vision in one eye, double vision, loss of coordination and trembling of a hand, instability in walking, spasticity, loss of bladder con¬trol, and peculiar spontaneous sensations such as pins-and-needles feeling over part of the body, called paresthesias. At first the patient may have only intermittent symptoms. Since the physical examination at this stage may be completely normal, the patient’s complaints may be dismissed initially as ‘pyschosomatic’ or ‘hysterical,'” Pedley explained.

While some patients may recover dramatically, MS is an incurable disease and the survival rate of sufferers can fall anywhere from a few weeks to 50 years. For relief of symptoms, the doctor may prescribe cortisone drugs together with physical therapy to retain muscle function.

“Adequate rest and sleep are important. Complications such as bed sores, contractures, spasms, and blad¬der and kidney infections can usually be prevented with physiotherapy and good nursing care. Excessive heat should be avoided. Psychotherapy may help in re¬habilitation. Very strenuous and fatiguing exercise is not beneficial and may be harmful,” said Kurt Butler and Dr. Lynn Rayner of the University Of Hawaii in “The Best Medicine.”

To strengthen your body, take Immunitril – your first line of defense in maintaining a healthy immune system. For details, visit http://www.bodestore.com/immunitril.html.

About the Author

Sharon Bell is an avid health and fitness enthusiast and published author. Many of her insightful articles can be found at the premier online news magazine http://www.HealthLinesNews.com.